Msh6 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comMsh6 Polyclonal Antibody for Mouse(Mus musculus)

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Msh6 (Gene name),

DNA mismatch repair protein Msh6 (Protein name ), MSH6_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Msh6(Gtmbp);

Protein name:

DNA mismatch repair protein Msh6;

Alternative:

MutS-alpha 160 kDa subunit;G/T mismatch-binding protein(GTBP;GTMBP);p160;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Heterodimer consisting of MSH2-MSH6 (MutS alpha). Forms a ternary complex with MutL alpha (MLH1-PMS1). Interacts with EXO1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with ATR.

Function:

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

1358

Sequence:

50:

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1150:

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1250:

1300:

1350:

1358:

LLALINGL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P54276

UniGene:

Mm.18210

Pfam:

PF01624

String:

P54276

KEGG:

mmu:17688

Uniprot:

P54276

FOR

ELISA Kit for Mouse DNA mismatch repair protein Msh6

Cat.:

E2360m

Price:

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MSDS:

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Packing:

96T

ELISA Kit for Mouse DNA mismatch repair protein Msh6

Cat.:

E2360h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse DNA mismatch repair protein Msh6

Cat.:

U2360m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse DNA mismatch repair protein Msh6

Cat.:

U2360h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse DNA mismatch repair protein Msh6

Cat.:

P2360Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse DNA mismatch repair protein Msh6

Cat.:

P2360Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse DNA mismatch repair protein Msh6

Protein for Mouse DNA mismatch repair protein Msh6

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"cDNA sequence, map, and expression of the murine homolog of GTBP, a DNA mismatch repair gene."
Corradi A. , Croci L. , Stayton C.L. , Gulisano M. , Boncinelli E. , Consalez G.G.
Genomics36:288-295(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Mutation in the mismatch repair gene Msh6 causes cancer susceptibility."
Edelmann W. , Yang K. , Umar A. , Heyer J. , Lau K. , Fan K. , Liedtke W. , Cohen P. , Kane M.K. , Lipford J.R. , Yu N. , Crouse G.F. , Pollard J.W. , Kunkel T. , Lipkin M. , Kolodner R. , Kucherlapati R.
Cell91:467-477(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: 129/Ola.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: FVB/N.
tissue: Mammary tumor.
4.

Donohue P.J. , Feng S.L.Y. , Alberts G.F. , Guo Y. , Peifley K.A. , Hsu D.K.W. , Winkles J.A.
Submitted (1996-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 375-425 AND 1001-1050
5.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.

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